Doctor Octopus, Master Planner

Legendary Creature — Human Scientist Villain

Doc Ock, Evil Inventor

Legendary Creature — Human Scientist Villain

Doctor Doom

Legendary Creature — Human Scientist Villain

Arnim Zola, Bio-Fanatic

Legendary Artifact Creature — Scientist Villain

Doctor Doom, King of Latveria

Legendary Creature — Human Noble Villain

Doc Ock's Henchmen

Creature — Human Villain

Nimana Skitter-Sneak

Creature — Human Rogue

Bramblefort Fink

Creature — Ouphe

Undercover Skrull

Creature — Skrull Shapeshifter Villain

Tenured Oilcaster

Creature — Phyrexian Wizard

The Masters of Evil

Legendary Creature — Human Villain

Crimson Cowl, Master of Evil

Legendary Creature — Human Villain

Baron Strucker, HYDRA Overlord

Legendary Creature — Human Villain

Madame Hydra

Legendary Creature — Human Villain

Venom, Eddie Brock

Legendary Creature — Symbiote Villain

M.O.D.O.K.

Legendary Artifact Creature — Villain

Oscorp Research Team

Creature — Human Scientist

Graveyard Busybody

Creature — Human Spy

Octavia, Living Thesis

Legendary Creature — Elemental Octopus

M.O.D.O.K., Evil Intellect

Legendary Artifact Creature — Villain

Deep-Sea Terror

Creature — Serpent

Madame Hydra, Reanimated

Legendary Creature — Human Horror Villain

Oko, the Ringleader

Legendary Planeswalker — Oko

Venom, Deadly Devourer

Legendary Creature — Symbiote Villain

Tombstone, Career Criminal

Legendary Creature — Human Villain

Doctor Doom, Unrivaled

Legendary Creature — Human Sorcerer Villain

Killmonger, Scourge of Wakanda

Legendary Creature — Human Mercenary Villain

Doctor Jane Foster

Legendary Creature — Human Doctor

Horror of the Dim

Creature — Horror

Prowler, Clawed Thief

Legendary Creature — Human Rogue Villain

Doc Ock's Tentacles

Artifact — Equipment